Pesquisa | Secretaria de Estado da Saúde

1.

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome.

Malachowski, Thomas; Chandradoss, Keerthivasan Raanin; Boya, Ravi; Zhou, Linda; Cook, Ashley L; Su, Chuanbin; Pham, Kenneth; Haws, Spencer A; Kim, Ji Hun; Ryu, Han-Seul; Ge, Chunmin; Luppino, Jennifer M; Nguyen, Son C; Titus, Katelyn R; Gong, Wanfeng; Wallace, Owen; Joyce, Eric F; Wu, Hao; Rojas, Luis Alejandro; Phillips-Cremins, Jennifer E.

Cell ; 186(26): 5840-5858.e36, 2023 12 21.

Artigo Inglês | MEDLINE | ID: mdl-38134876

2.

Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4⁺ T cell reservoir.

Wu, Vincent H; Nordin, Jayme M L; Nguyen, Son; Joy, Jaimy; Mampe, Felicity; Del Rio Estrada, Perla M; Torres-Ruiz, Fernanda; González-Navarro, Mauricio; Luna-Villalobos, Yara Andrea; Ávila-Ríos, Santiago; Reyes-Terán, Gustavo; Tebas, Pablo; Montaner, Luis J; Bar, Katharine J; Vella, Laura A; Betts, Michael R.

Nat Immunol ; 24(2): 359-370, 2023 02.

Artigo Inglês | MEDLINE | ID: mdl-36536105

3.

Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer.

Johnstone, Sarah E; Reyes, Alejandro; Qi, Yifeng; Adriaens, Carmen; Hegazi, Esmat; Pelka, Karin; Chen, Jonathan H; Zou, Luli S; Drier, Yotam; Hecht, Vivian; Shoresh, Noam; Selig, Martin K; Lareau, Caleb A; Iyer, Sowmya; Nguyen, Son C; Joyce, Eric F; Hacohen, Nir; Irizarry, Rafael A; Zhang, Bin; Aryee, Martin J; Bernstein, Bradley E.

Cell ; 182(6): 1474-1489.e23, 2020 09 17.

Artigo Inglês | MEDLINE | ID: mdl-32841603

4.

The Identity of Human Tissue-Emigrant CD8⁺ T Cells.

Buggert, Marcus; Vella, Laura A; Nguyen, Son; Wu, Vincent H; Chen, Zeyu; Sekine, Takuya; Perez-Potti, André; Maldini, Colby R; Manne, Sasikanth; Darko, Samuel; Ransier, Amy; Kuri-Cervantes, Leticia; Japp, Alberto Sada; Brody, Irene Bukh; Ivarsson, Martin A; Gorin, Jean-Baptiste; Rivera-Ballesteros, Olga; Hertwig, Laura; Antel, Jack P; Johnson, Matthew E; Okoye, Afam; Picker, Louis; Vahedi, Golnaz; Sparrelid, Ernesto; Llewellyn-Lacey, Sian; Gostick, Emma; Sandberg, Johan K; Björkström, Niklas; Bar-Or, Amit; Dori, Yoav; Naji, Ali; Canaday, David H; Laufer, Terri M; Wells, Andrew D; Price, David A; Frank, Ian; Douek, Daniel C; Wherry, E John; Itkin, Maxim G; Betts, Michael R.

Cell ; 183(7): 1946-1961.e15, 2020 12 23.

Artigo Inglês | MEDLINE | ID: mdl-33306960

5.

TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors.

Wang, Wenliang; Chandra, Aditi; Goldman, Naomi; Yoon, Sora; Ferrari, Emily K; Nguyen, Son C; Joyce, Eric F; Vahedi, Golnaz.

Nat Immunol ; 23(7): 1052-1062, 2022 07.

Artigo Inglês | MEDLINE | ID: mdl-35726060

6.

Targeting of intracellular oncoproteins with peptide-centric CARs.

Yarmarkovich, Mark; Marshall, Quinlen F; Warrington, John M; Premaratne, Rasika; Farrel, Alvin; Groff, David; Li, Wei; di Marco, Moreno; Runbeck, Erin; Truong, Hau; Toor, Jugmohit S; Tripathi, Sarvind; Nguyen, Son; Shen, Helena; Noel, Tiffany; Church, Nicole L; Weiner, Amber; Kendsersky, Nathan; Martinez, Dan; Weisberg, Rebecca; Christie, Molly; Eisenlohr, Laurence; Bosse, Kristopher R; Dimitrov, Dimiter S; Stevanovic, Stefan; Sgourakis, Nikolaos G; Kiefel, Ben R; Maris, John M.

Nature ; 623(7988): 820-827, 2023 Nov.

Artigo Inglês | MEDLINE | ID: mdl-37938771

7.

High-throughput Oligopaint screen identifies druggable 3D genome regulators.

Park, Daniel S; Nguyen, Son C; Isenhart, Randi; Shah, Parisha P; Kim, Wonho; Barnett, R Jordan; Chandra, Aditi; Luppino, Jennifer M; Harke, Jailynn; Wai, May; Walsh, Patrick J; Abdill, Richard J; Yang, Rachel; Lan, Yemin; Yoon, Sora; Yunker, Rebecca; Kanemaki, Masato T; Vahedi, Golnaz; Phillips-Cremins, Jennifer E; Jain, Rajan; Joyce, Eric F.

Nature ; 620(7972): 209-217, 2023 Aug.

Artigo Inglês | MEDLINE | ID: mdl-37438531

8.

p53 mediates target gene association with nuclear speckles for amplified RNA expression.

Alexander, Katherine A; Coté, Allison; Nguyen, Son C; Zhang, Liguo; Gholamalamdari, Omid; Agudelo-Garcia, Paula; Lin-Shiao, Enrique; Tanim, K M A; Lim, Joan; Biddle, Nicolas; Dunagin, Margaret C; Good, Charly R; Mendoza, Mariel R; Little, Shawn C; Belmont, Andrew; Joyce, Eric F; Raj, Arjun; Berger, Shelley L.

Mol Cell ; 81(8): 1666-1681.e6, 2021 04 15.

Artigo Inglês | MEDLINE | ID: mdl-33823140

9.

Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression.

Gozalo, Alejandro; Duke, Ashley; Lan, Yemin; Pascual-Garcia, Pau; Talamas, Jessica A; Nguyen, Son C; Shah, Parisha P; Jain, Rajan; Joyce, Eric F; Capelson, Maya.

Mol Cell ; 77(1): 67-81.e7, 2020 01 02.

Artigo Inglês | MEDLINE | ID: mdl-31784359

10.

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.

Yarmarkovich, Mark; Marshall, Quinlen F; Warrington, John M; Premaratne, Rasika; Farrel, Alvin; Groff, David; Li, Wei; di Marco, Moreno; Runbeck, Erin; Truong, Hau; Toor, Jugmohit S; Tripathi, Sarvind; Nguyen, Son; Shen, Helena; Noel, Tiffany; Church, Nicole L; Weiner, Amber; Kendsersky, Nathan; Martinez, Dan; Weisberg, Rebecca; Christie, Molly; Eisenlohr, Laurence; Bosse, Kristopher R; Dimitrov, Dimiter S; Stevanovic, Stefan; Sgourakis, Nikolaos G; Kiefel, Ben R; Maris, John M.

Nature ; 599(7885): 477-484, 2021 11.

Artigo Inglês | MEDLINE | ID: mdl-34732890

11.

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Petrovic, Jelena; Zhou, Yeqiao; Fasolino, Maria; Goldman, Naomi; Schwartz, Gregory W; Mumbach, Maxwell R; Nguyen, Son C; Rome, Kelly S; Sela, Yogev; Zapataro, Zachary; Blacklow, Stephen C; Kruhlak, Michael J; Shi, Junwei; Aster, Jon C; Joyce, Eric F; Little, Shawn C; Vahedi, Golnaz; Pear, Warren S; Faryabi, Robert B.

Mol Cell ; 73(6): 1174-1190.e12, 2019 03 21.

Artigo Inglês | MEDLINE | ID: mdl-30745086

12.

Pasa: leveraging population pangenome graph to scaffold prokaryote genome assemblies.

Do, Van Hoan; Nguyen, Son Hoang; Le, Duc Quang; Nguyen, Tam Thi; Nguyen, Canh Hao; Ho, Tho Huu; Vo, Nam S; Nguyen, Trang; Nguyen, Hoang Anh; Cao, Minh Duc.

Nucleic Acids Res ; 52(3): e15, 2024 Feb 09.

Artigo Inglês | MEDLINE | ID: mdl-38084888

13.

Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression.

Luppino, Jennifer M; Field, Andrew; Nguyen, Son C; Park, Daniel S; Shah, Parisha P; Abdill, Richard J; Lan, Yemin; Yunker, Rebecca; Jain, Rajan; Adelman, Karen; Joyce, Eric F.

PLoS Genet ; 18(11): e1010528, 2022 11.

Artigo Inglês | MEDLINE | ID: mdl-36449519

14.

Structural Characterization of a Pathogenic Antibody Underlying Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT).

Nguyen, Son N; Le, Si-Hung; Ivanov, Daniil G; Ivetic, Nikola; Nazy, Ishac; Kaltashov, Igor A.

Anal Chem ; 96(16): 6209-6217, 2024 Apr 23.

Artigo Inglês | MEDLINE | ID: mdl-38607319

15.

Interactions and Transport of a Bioconjugated Peptide Targeting the Mitomembrane.

Nguyen, Son V; Levintov, Lev; Planalp, Roy P; Vashisth, Harish.

Bioconjug Chem ; 35(3): 371-380, 2024 Mar 20.

Artigo Inglês | MEDLINE | ID: mdl-38404183

16.

Controllable electronic properties, contact barriers and contact types in a TaSe₂/WSe₂ metal-semiconductor heterostructure.

Nguyen, Son T; Cuong Q, Nguyen; N Hieu, Nguyen; Phuc, H V; Nguyen, Ch V.

Phys Chem Chem Phys ; 26(12): 9657-9664, 2024 Mar 20.

Artigo Inglês | MEDLINE | ID: mdl-38469888

17.

Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.

Yarmarkovich, Mark; Marshall, Quinlen F; Warrington, John M; Premaratne, Rasika; Farrel, Alvin; Groff, David; Li, Wei; di Marco, Moreno; Runbeck, Erin; Truong, Hau; Toor, Jugmohit S; Tripathi, Sarvind; Nguyen, Son; Shen, Helena; Noel, Tiffany; Church, Nicole L; Weiner, Amber; Kendsersky, Nathan; Martinez, Dan; Weisberg, Rebecca; Christie, Molly; Eisenlohr, Laurence; Bosse, Kristopher R; Dimitrov, Dimiter S; Stevanovic, Stefan; Sgourakis, Nikolaos G; Kiefel, Ben R; Maris, John M.

Nature ; 623(7988): 872, 2023 Nov.

Artigo Inglês | MEDLINE | ID: mdl-37938785

18.

Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood.

Brownlie, Demi; Scharenberg, Marlena; Mold, Jeff E; Hård, Joanna; Kekäläinen, Eliisa; Buggert, Marcus; Nguyen, Son; Wilson, Jennifer N; Al-Ameri, Mamdoh; Ljunggren, Hans-Gustaf; Marquardt, Nicole; Michaëlsson, Jakob.

Proc Natl Acad Sci U S A ; 118(11)2021 03 16.

Artigo Inglês | MEDLINE | ID: mdl-33836578

19.

Reverse Engineering of a Pathogenic Antibody Reveals the Molecular Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia.

Ivanov, Daniil G; Ivetic, Nikola; Du, Yi; Nguyen, Son N; Le, S Hung; Favre, Daniel; Nazy, Ishac; Kaltashov, Igor A.

J Am Chem Soc ; 145(46): 25203-25213, 2023 11 22.

Artigo Inglês | MEDLINE | ID: mdl-37949820

20.

3D mapping and accelerated super-resolution imaging of the human genome using in situ sequencing.

Nguyen, Huy Q; Chattoraj, Shyamtanu; Castillo, David; Nguyen, Son C; Nir, Guy; Lioutas, Antonios; Hershberg, Elliot A; Martins, Nuno M C; Reginato, Paul L; Hannan, Mohammed; Beliveau, Brian J; Church, George M; Daugharthy, Evan R; Marti-Renom, Marc A; Wu, C-Ting.

Nat Methods ; 17(8): 822-832, 2020 08.

Artigo Inglês | MEDLINE | ID: mdl-32719531

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Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome.

Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4⁺ T cell reservoir.

Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer.

The Identity of Human Tissue-Emigrant CD8⁺ T Cells.

TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors.

Targeting of intracellular oncoproteins with peptide-centric CARs.

High-throughput Oligopaint screen identifies druggable 3D genome regulators.

p53 mediates target gene association with nuclear speckles for amplified RNA expression.

Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression.

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Pasa: leveraging population pangenome graph to scaffold prokaryote genome assemblies.

Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression.

Structural Characterization of a Pathogenic Antibody Underlying Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT).

Interactions and Transport of a Bioconjugated Peptide Targeting the Mitomembrane.

Controllable electronic properties, contact barriers and contact types in a TaSe₂/WSe₂ metal-semiconductor heterostructure.

Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.

Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood.

Reverse Engineering of a Pathogenic Antibody Reveals the Molecular Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia.

3D mapping and accelerated super-resolution imaging of the human genome using in situ sequencing.